Avocado Oil is a rich, heavy, penetrating oil, high in sterolins, with 20 % essential unsaturated fatty acids; vitamins A, C, D and E, proteins, beta-carotene, lecithin, fatty acids, and potassium.

  Black Cohosh (Cimicifuga racemosa, 4:1 extract) is one of the world's most famous herbs for women's health. Women throughout the world, both young and old, use Black Cohosh regularly to help them stay balanced during their monthly cycle. It's naturally relaxing and helps calm the senses without side-effects or chemical dependency. Black Cohosh is also very popular for relaxing a stiff, achy body.
   There is evidence that actives in black cohosh blocks the estrogen receptor. Reducing estrogen levels will reduce prolactin levels, thereby, promoting menstrual flow. The salicyclic acid makes it useful for inflammatory conditions like arthritis.
   During the menopausal period, there is a gradual failure of the ovaries to produce estrogens and progesterone. Through a negative feedback mechanism the pituitary gland produces follicle stimulating hormone (FSH) and luteinizing hormone (LH) in great quantities. FSH and LH trap or use up much of the estrogen and progesterone in your body, generally in a unbalance way, thus the large quantities of FSH and LH causes hormonal imbalance resulting in most of the symptoms of menopause; anxiety, emotional instability, irritability, insomnia, hot flushes and cold sweats. Black Cohosh, through an unknown mechanism, blocks this high FSH and LH secretion, thus assisting to balance hormones.
   Black Cohosh’s main actives are: Triterpene glycoside; actein, 27-deoxyactein, cimicifugoside; phenylpropane derivatives, isoferulic acid; the isoflavone Formononetin; Tannins; Salicylic acid; Resin.

   Calcium Citrate micronized. Helps build bone, and assists the other ingredients to be absorbed, and activated in the body. Extremely good for skin nutrition.

   Chamomile (8:1 extract) has a high content of the amino acid tryptophan that has been used for sleeplessness & insomnia. It is used to calm the nerves and reduce anxiety, and induce a state of pleasant relaxation without disrupting normal function or interfering with motor coordination. Its natural soothing properties make it valuable for supporting healthy nervous system function.
   The active principles are a volatile oil of pale blue color, a little Anthemic acid, tannic acid and a glucoside.
   Chamomile's effectiveness is also due to its anti-inflammatory properties, soothing ulcers and reducing gastritis and other mucous membrane inflammations.
   In one study it was found that chamomile was 60% as active as a topical corticosteroid cream. Another study using patients with atopic dermatitis, it was found to be nearly as effective as hydrocortisone.

   DHEA, USP Micornized (Bio-Identical) supplementation has proven to have potent anti-aging effects, increasing energy, vitality, memory, and physchological sense of well being. Blood levels of DHEA and its circulating metabolite DHEA-sulfate (DHEA-S), decline greatly from youth to old age. The decline continues gradually throughout life until, by 80, the levels remain at about 20% of levels in youth. Clinical evidence clearly correlates DHEA decline with many aging related health problems. Regular supplementation of DHEA to restore youthful levels of the hormone has prevented aged related health problems in thousands of people worldwide.

   Glycerin, Vegetable draws moisture from the air to the skin. Glycerin makes the skin feel softer and smoother, reduces rough feeling, cracking and irritation. Glycerin has a high hydrophilic (water) factor and a low lipophilic (fat) factor. Glycerin helps the water and oil ingredients absorb through the skin.

   Jojoba Seed Oil (Simmondsia chinensis) is pronounced “Ho Ho Ba”. Jojoba is actually not an oil, but a liquid wax ester with long unsaturated carbon chains just like your skin. Jojoba resembles human sebum, the natural coating our body produces to protect the skin. Jojoba works so well because it actually penetrates the skin making your skin supple and healthy, plus it helps to deliver other important ingredients through the skin.

   Magnesium Citrate attracts and retains water to the extract solids, keeping the extracts fluid and absorbable It helps the skin re-moisturize.

   Magnesium Stearate is a derivative of an essential mineral. It Diffuses the ingredients evenly throughout the cream.

   Methylparaben (Methyl p-hydroxybenzoate) Methyl p-hydroxybenzoate comes from the combination of denatured wood alcohol and benzoic acid. Benzoic acid occurs naturally in cherry bark, raspberries, tea, anise and cassia bark. In small amounts it is neutral, nontoxic, safe to use, nonirritating, nonsensitizing and nonpoisonous.

   Natural Mixed Tocopherols and Tocotrienols (Vitamin E) acts as free radical scavengers, hindering the oxidizing process. Antioxidants are used in Vital Effects Tri-Gesterone DAILY™ Bio-Identical Hormone Cream to neutralize free radicals before they ravage your body.

   Natural Vegetable Emulsifiers. Palm and Coconut oil esters. An emulsifier is a natural or chemical compound that joins oil and water and forms a stable mixture called an emulsion. A critical ingredient in creams since there is no other natural product that can create a stable mixture.
     Stearic Acid. (Palm) A vegetable derived natural fatty acid that adds a protective micro layer to your skin.
    Myristic Myristate is essential for the absorbtion of most of the protein in any cream. Skin creams that are made without myristate acid leave many of their proteins on your skin surface, doing nothing for you, where they are washed or worn away.
Myristic Myristate is made by combining natural oils with vegetable myristic acid to form a water-soluble ester.
    Myristic acid, or the myristoyl group of acids is one of the less common fatty acyl residues of phospholipids found in tissue membranes throughout your body. In all known examples, the myristoyl is attached to the amino acid group of “N” terminal glycine found in a majority of proteins. The addition of the myristoyl acid group is essential for membrane association of these proteins.
     With Tri-Gesterone•DAILY™ Triple Fortified Added Strength Progesterone Cream superior formula that includes Myristic acid, the billions of proteins in the cream are allowed to penetrate your skin, along with the other healthy ingredients, healing and nourishing your entire body.

   Pregnenolone, USP Micronized (Bio-Identical) helps proper balancing of estrogen, testosterone, DHEA, progesterone, cortisol and aldosterone (salt regulating hormone). It is the most abundant hormone in the body. It is the root of almost all hormones.    Pregnenolone is one of the most potent brain nutrients available. It normalizes and regulates steroid hormones, and is anti-depressive. It improves mental energy levels, alertness, and prevents fatigue. It enhances memory and cognition. Pregnenolone has proven beneficial in treating PMS, menopause, and arthritis, and is anti-inflammatory. It prevents excessive cortisol buildup and helps reduce the harmful effects of stress.
   Pregnenolone strengthens the myelin sheath membranes of nerve cells, which is vital for a healthy central nervous system. Pregnenolone levels decline with age. Use at least 2 to 3 months to feel its overall healing results.

   Proprietary Herbal Extract Blend. An amazing proprietary herbal extract blend of highly researched herbal extracts. Its 18 synergistic extracts are reported to work together to lighten mood, relieve stress, lessen or eliminate pms and menopausal symptoms, and increase energy. The amazing blended extracts are: Rehmannia Root, Chinese Rose, Bupleurum Root, Szechuan Pagoda Tree Fruit, Selfheal Spike, Sweetgum Fruit, Chinese Angelica Root, Feng Fang, Vaccaria Seeds, White Peony Root, Ligusticum Root, Curuma Tuber, Tribulus, Siler Root, Jasmine Fruit, Moutan Root Bark, Cyperus Rhizoma, Licorice Root.

 Propylparaben (Propyl-4-hydroxybenzoate) Esters of p–Hydroxybenzoate. Hydroxybenzoate is hydrogenated benzoic acid oil. Benzoic acid oil occurs naturally in cherry bark, raspberries, tea, anise and cassia bark. Widely used in cosmetics as a preservative against bacteria and fungus. In small amounts it is neutral, nontoxic, safe to use, nonirritating, nonsensitizing and nonpoisonous.

   Siberian Ginseng or Eleuthero Root, Concentrated 50:1 extract. It is a member of the ginseng family, though it is of a different genus than other popular ginsengs such as the Panax variety. Siberian Ginseng is an energizer and a mood stabilizer. It has a mild estrogenic effect, and may combine with other mild, or weak estrogenic compounds to displace the harmful strong estrogens in the body. Oxygenates the blood, and increases fat metabolism. Eleuthero is a substance that may help individuals cope with physical and emotional stress.

   Sweet Almond Oil Contains glucosides, minerals, and vitamins and is rich in protein. It consist mainly of oleic acid (69%), essential unsaturated fatty acids (25%), sterolins (.5 to 1%) and vitamin E (about 10 IU per ounce). Sweet almond oil has a similar make up to baby’s sebum, the oil naturally produced by the skin to protect it, and is easily absorbed.

   Vegetable Diindolemethane (DIM) effects include: reducing estrogen cell receptor activity; promotion of the “good” 2-hydroxy estrogens; and by supporting selective programmed cell death, DIM allows the body to remove damaged cells prone to hurt you.
   Human studies showed that DIM resulted in a 75% increase in good 2-hydroxy estrogens with a 50% decrease in bad 16-hydroxyestrone estrogens linked to disease onset.
   DIM isn't itself a phytoestrogen or an estrogen mimic. Thus, there is no danger of a pro-estrogen effect with DIM.
   DIM promotes beneficial estrogen metabolism in both women and men and regulates free testosterone levels. In women, the proper balance between estrogen metabolism and free testosterone supports positive mood, increased libido, fat burning, supple skin, strong bones, healthy joints and cardiovascular protection.
   Diindolemethane is from cruciferous vegetables. 4 1/2 pounds of broccoli is equivalent to 100 mg of DIM!

   Water (Distilled) is the primary ingredient in almost every product used by humans from food and drinks, and for cleansing and cosmetic items. Quality formulations begin with high purity water. Water is a very powerful dipolar solvent so that the naturally occurring supply from springs, lakes and rivers always contain some minerals, gases and organic materials which may have adverse affects on manufactured products. This is why we use only purified distilled water in Vital Effects Tri-Gesterone DAILY™ Bio-Identical Hormone Cream.

   Witch Hazel is a natural, non-drying astringent, anti-inflammatory, and mild sedative that contains: hamamelitannin, gallic acid, saponins, resin, flavonoids (quercitin, kaempferol, astragalin, myricitrin), and volatile oil.
   It is proven to relieve external soreness of muscles, muscular aching, sore breasts, bruises, sprains and localized inflammation and swellings, varicose veins, spots and blemishes, hemorrhoids, vulva bruising, vaginal laxity with tenderness, inflamed sore throat, sore and bloodshot eyes. It is very helpful when applied to insect bites and minor burns such as sunburn.

   Ascorbyl palmitate (Palmitic acid ester - Vitamin C Ester) A salt of ascorbic acid. Vitamin C is thought to prevent collagen break down and help combat the signs of aging. As an antioxidant it is believed to remove the free radicals that cells produce. Topical vitamin C may help lighten solar lentigos and melasma.

   Borage Seed Oil (Borago officinalis) The most amazing natural oil on Earth. Borage oil is 20 to 26% gamma linolenic acid (GLA), a fatty acid that the body converts to a hormone-like substance called prostaglandin E1 (PGE1). PGE1 has anti-inflammatory properties and may also act as a blood thinner, blood vessel dilator, and a regulator of a host of bodily functions. Borage oil also has the highest known content of essential unsaturated fatty acids.
   Borage oil is used for many conditions. One preliminary medical trial and two double-blind trials have shown that borage oil reduces symptoms of rheumatoid arthritis. Borage oils has been shown to be effective in relieving PMS, menopausal symptoms, pain and discomfort.

   Burdock Root (4:1 extract) is rich in Vitamins B-1, B-6, B-12, and E, plus manganese, copper, iron, zinc, sulfur, and more. Burdock Root has been used both internally and externally for eczema and psoriasis, as well as to treat painful joints. It also aids in the elimination of uric acid. The herb contains polyacetylenes that have both antibacterial & antifungal properties. The polyacetylene constituents have also been shown to have antimicrobial activity. Burdock Root (and the fruit) also have the ability to mildly lower blood sugar.
   Up to seventy-five percent of the Burdock Root is made up of complex carbohydrates known as fructo-oligo-saccharides (FOS), including 27-45% inulin. FOS significantly increases beneficial bifidobacteria within the gastrointestinal tract and eliminates bacterial pathogens. This ultimately stimulates the immune system and effectively suppresses abnormal cell growth. The high levels of FOS in burdock root and its water extract also help to keep blood sugar levels constant and reduce hyperglycemia. Burdock root also contains at least five powerful flavonoid-type antioxidants that are more powerful antioxidants than vitamin C. It aids digestion and cleanses the liver. The qualities of burdock root support proper hormone balances within the body and its traditional use for treating acne, eczema, endometriosis, fibroids and psoriasis.

   Coenzyme Q10, or Ubiquinone, is a vitamin-like substance acting similar to Vitamin E. Research shows it is a more powerful antioxidant. CoQ10 is critical to the production of energy in every cell of the body. It aids in circulation, stimulates the immune system, increases tissue oxygenation, and has vital anti-aging effects.

   DMAE Bitartrate (Bio-Identical) (Dimethylaminoethanol Bitartrate) extends the life of cells throughout the entire body, and is found in every cell of the body. It is one of the most important brain nutrients in conjunction with pregnenolone. It helps all functions of the brain, especially in the transport of nutrients and hormones in and out of the brain. When applied to the face DMAE stimulates a response in face muscles, creating a firmer facial tone and less sagging. DMAE can cause a slight tingling sensation.

   Lecithin (Natural) is a lipid that is required by every single cell in your body. The cell membranes that handle the flow of nutrients in and out of the cell are composed largely of lecithin. The protective sheaths around your brain are also made of lecithin. Muscles and nerve cells also use lecithin. Lecithin is used to prevent arteriosclerosis, protect against cardiovascular disease, improve brain function, increase energy levels, repair damage from alcoholism, help in digestion of fats. It combats aging, immune system disorders, AIDS, herpes, and chronic fatigue syndrome.
   A natural antioxidant and emollient, Lecithin is made up of many different phospholipids. Phospholipids’ structures allow special protein molecules to selectively transport ions through cell membranes. Phospholipids are a phosphor compound with phosphate ester, a necessary nutrient for bone formation and remodeling. The phosphor compound also increases the water affinity of glyceride.
    Lecithin has the ability to penetrate the epidermis and carry substances to the cell level. It forms cell-like structures called Liposomes. Liposomes are formed when ever a group of phospholipids are placed on the skin; they spontaneously arrange themselves to match their water loving heads together and their oil loving tails together to form a microscopic sphere. These spheres are similar in construction to an actual cell membrane. They are then able to pass through the skin and act as a carrier of substances that attach themselves. Vital Effects Tri-Gesterone DAILY™ Bio-Identical Hormone Cream is a liposomal product.

   MSM (methylsulfonylmethane) is marketed for a range of ailments including pain and inflammation from rheumatoid arthritis (RA), osteoarthritis (OA), fibromyalgia and gout; and to correct constipation, relieve allergies, control stomach acidity and - believe it or not - stop snoring. However, there’s not much on which to base these claims, even now, there are no scientifically accepted human studies, and what works in animals doesn’t always work in humans.What we do know about MSM is that when properly prepared in a transdermal treatment, MSM increases absorption of that treatment’s ingredients by as much as 100%. It is for the overall enhanced absorption of all ingredients that MSM is now used in Tri-Gesterone•DAILY™ Triple Fortified Added Strength Progesterone Cream.

   Panthenol (Pro-Vitamin B5) is a Vitamin B5 Complex that is great for human tissues. No known toxicity and is non-sensitizing. Improves and increases the moisture-retention capacity of the skin. Dry skin stays supple and elastic for longer. Anti-inflammatory and anti-itching effect. Stimulates skin regeneration. Small wounds, scratches and blisters heal better. Panthenol greatly increases the water retention capacity of the fingernails, thus increasing their flexibility and stability.

   Progesterone, USP Micronized (Bio-Identical) is a main hormones in male and female bodies. It is used in hundreds of life cycle processes in all regions of the human body. A majority of progesterone is captured by proteins and other molecules and used in ways other than what we conventionally believe progesterone is for. Very little of our progesterone is used in our bodies for reproductive organs. As such, it takes very little free progesterone supplementation to balance our bodies.
   Progesterone needs to be in balance for the body to be healthy, and mood to be good. A correct supply of Progesterone is essential for a healthy estrogen supply and is a balancer of our many estrogens. Use at least 2 to 3 months to feel its healing results.

   Propylene Glycol is one of the most powerful anti-oxidents known. Often derived from lactic acid, glucose, or seaweed. It can penetrate the outermost layer of the skin cells and carry other beneficial products deeper into the epidermis. The most common moisture carrying ingredient other than water used in cosmetics because it moisturizes better than glycerin. It turns into water in the body in 4 hours. It is used as a wetting agent and surfactant which gives a product better absorption and promotes spreading of the product on the skin. Originally derived from brown algae, it has been used for almost a century. Propylene Glycol is also a natural product of fermentation that is found in all beers and wines.

   Safflower Oil (Simmondsia chinensis) is extremely penetrating. It is high in fatty acids that help the skin to heal and moisturize.

   Shea and Mango Butters are extremely therapeutic, helping to heal cracked, aged and damaged skin. Their constituents help to heal bruising and soreness. They have vitamin A, E and are highly compatible with skin, penetrating it and leaving it feeling soft and smooth. These butters have a high content of unsaponifiables (sterolins) and cinnamic esters, which have antimicrobial and moisturizing properties.

   Hesperidin Complex is a Citrus Bioflavonoid - a natural substance found in plants, fruits, vegetables, nuts, bark, and buckwheat. Hesperidin seems to work by improving venuous tone, reducing stasis, restoring normal capillary permeability, and improving lymphatic drainage. Hesperidin appears to have anti-inflammation, antioxidant, and analgesic effects. Hesperidin helps alleviate hot flashes by improving capillary strength and maintaining vascular integrity, reducing the physiologic potential for flushing.Citrus Bioflavonoids help protect capillaries, prevent bruising, and intensify the effect of vitamin C in the body. In fact, Bioflavonoids are essential for total vitamin C effectiveness. Daily use can be helpful to those suffering from spider veins, arthritis, bruising, varicose veins, and fragile capillaries, hemorrhage, phlebitis, high cholesterol levels, herpes, cataracts, general inflammation, bleeding gums, blood clots, scurvy, hemorrhoids, edema, and hypertension.

   Vitamin A is an antioxidant that aids in the removal of free radicals. Research shows that vitamin A encourages collagen production in the dermis, which causes the middle layers of your skin to plump out and efficiently retain moisture.

   Vitamin D3 or Calcitriol promotes the body's absorption of calcium, which is essential for the normal development and maintenance of healthy teeth and bones. Vitamin D also helps maintain adequate blood levels of calcium and phosphorus. Vitamin D is recommended in the treatment of osteoporosis in postmenopausal women and is essential for strong pelvic bones. The biologically active form of vitamin D is a hormone known as calcitriol.
   Vitamin D is involved in normal cell growth and maturation. Parts of the bone marrow which produce immune cells are receptive to vitamin D.
   Vitamin D plays a role in the secretion of insulin by the pancreas thus aiding in the regulation of blood sugar. It also affects the parathyroid gland and a hormone that it produces.

   Wild Yam Extract, Concentrated 30:1 extract, (Dioscorea villosa) contains a multitude of weak estrogen-like compounds that have been used to effectively treat a variety of medical problems, and is used as a spasmolytic, mild diaphoretic, anti-inflammatory, and anti-rheumatic. Wild Yam does not contain progesterone nor anything else that acts like progesterone.