Why Low Dose Hormones Are The Wise Healthy Choice.
	Q. How much progesterone does your cream have per ounce? A. Every time a hormone is metabolized from one form to another there is a greater loss of the original hormone than is converted into the target hormone. Thus, the conversion process often releases free radicals of one size/kind or another. It is best to have as few conversions as necessary. By providing progesterone, pregnenolone, calcitriol and DHEA hormones directly, in addition to the estrogenic and hormonal oils, supplements and herbs, Tri-Gesterone•DAILY™ saves you from excessive metabolic loss of hormones, and from the free radicals produced in great abundance from the cascading metabolization that happens when just one hormone is used in high doses. As such, multiple supplemental hormones, as found in Tri-Gesterone•DAILY™, are provided in balanced low dose amounts to bring balance to your hormonal systems without harmfully overdosing your body. At this time, few people know or understand what the amounts (dosage) of the various hormones and other ingredients should be when they are combined in a multi-hormone transdermal cream as Tri-Gesterone•DAILY™. Most women have been taught to judge hormone creams based on the misinformed idea of "highest progesterone per ounce", looking for the highest dose possible. Ending up with a high doese progesterone cream that could very well hurt you.      The correct question people should ask is: "Does this cream contain a well formulated wide spectrum of hormone balancing agents to balance out the real life wide spectrum of hormones found in my human body, without overdosing me, or causing me harm?" The answer to this questions is the one and only low dose multi-hormonal cream, Tri-Gesterone•DAILY™ Triple Fortified Added Strength Progesterone Cream. Q. Are there any side effects to progesterone use? A. Yes. Progesterone, DHEA, most all the estrogens and androgens have a "negative feedback loop". This causes a problem with long term use of large doses of most hormones. The negative feedback loop is where your body changes its basic operating procedures in the face of ongoing hormone supplementation/replacement. Sometimes, over the short term, the change is for the best, such as when a person's production of estrogen is to high and needs to be down regulated. However, the changes are just as often unhealthy, causing over time a down regulation of a person's own hormone production as the body desperately attempts to balance-out a massive continual overdose, thus causing a person to need even greater amounts of the overdosed hormone to "feel good", and slowly harms the person because of continual forced imbalance from the exogenous hormonal overdosing transdermal application.      The idea that excess hormonal application is simply flushed from the body before harm is done is inaccurate and untrue. Hormones are much to powerful of agents. This has been documented for women that have been on high doses of progesterone from transdermal creams of 480mgs/oz for as little as 12 months, and includes excessive menstrual bleeding, swollen glands in various parts of the body, excessive metabolizing of overdosed progesterone into testosterone, excessive sleepiness, the return of menstruation for post-menopausal women.      In one study1, micronized progesterone at a dose equal to 40 mg per day transdermal was associated with dizziness, abdominal cramping, headache, breast pain, muscle pain, irritability, nausea, fatigue, diarrhea, and viral infections 1. Arky R. Physicians' Desk Reference. 53rd edition. Montvale, NJ: Medical Economics; 1999:125.			Progesterone is fat soluble and can be stored in the body for several days before being "flushed" from your body. Transdermal progesterone may pass several fat layers before entering your system, and is more easily stored in your body than your native progesterone which is released to the blood stream first, and is mostly used before it can be stored in the fat cells of your body. This is one reason why overdosing is so easy with high doese transdermal progesterone creams. Over time, many women using the "regular" dose of 20mg per day will become overdosed and have the problems of progesterone dominance.      However, because the many documented problems of high dose progesterone have never been subjected to the rigors of FDA accepted clinical analysis, and thus not officially recognized by the traditional medical industry, the makers of high dose progesterone creams feel free to claim there are no side effects to their products. The same medical industry that is so condemned for their use of harmful fake hormones is used as a shield of protection by high dose "natural" progesterone cream manufacturers. High doses of any hormone can never be called "natural". The lure of the high dose creams is instant, but far from healthy, gratification.      It has been proven in hundreds of studies of many hormones since 1971 that when it comes to hormones, more is rarely better, even for bio-identical hormones. Tri-Gesterone•DAILY™ Triple Fortified Added Strength Progesterone Cream does not attempt a full replacement of any one hormone. It is a low dose supplemental transdermal multi-hormonal cream that is formulated to be healthy for the vast majority of women to use long-term (life long if necessary) without harm. Because it is low dose, Tri-Gesterone•DAILY™ may take up to 2 months to take full effect in the body. We suggest using two jars in the first month, which usually brings a body into the "feel good" stage, and then a jar each month thereafter. Q. Doesn't science support high dose creams? A. None of the studies or science supporting high dose progesterone creams is accepted by the FDA. There are more studies showing more harm or discomfort from high dose hormones, including progesterone, than studies that demonstrate the opposite, more benefits than harm. The big problem concerning transdermal progesterone research is that many of the studies concerning progesterone supplementation are flawed in procedure and conclusion.      Understanding the science is difficult and confusing. We have found that reading Dr. Betty Kamen's book entitled "Hormone Replacement Therapy, Yes or No, How To Make An Informed Decision" explains the concepts and research in the most accurate detail, including over 5000 authoritative references on the subject. Dr. Kamen has a Ph.D. in Nutrition Education. We also highly recommend reading "Better Bones, Better Body" by Dr. Susan Brown, Ph.D. in social anthropology. It is the best book on Osteoporosis available, and includes over 3000 authoritative references.      Balancing the hormonal agents in a cream is actually difficult. The research and expertise to do so is expensive. This is another reason why the hype on single hormone creams is so intense. Those types of cream are easy and cheap to make, sell, and justify. Many manufacturers of high dose progesterone creams are small cosmetic companies that read a few books, and formulate a simple high dose cream without any real knowledge concerning progesterone at all. Tri-Gesterone•DAILY™ was formulated by Vital Effects' Ph.D. Chemist, in consultation with several M.D.'s, herbalists, and Dr. Betty Kamen, Ph.D.      The original science concerning progesterone creams from the late seventies and early eighties was a great step forward. However, much has been discovered since then, and that early science is now outdated. Tri-Gesterone•DAILY™'s formula is highly researched and based on the latest science. It is formulated to bring a healthy balance as best as science (both traditional and alternative) can deliver today.